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https://onlinelibrary.wiley.com/doi/full/10.1111/j.1365-2869.2004.00385.x
Sleep disturbances in DM1 patients and controls Sleep/wake schedule. On average, DM1 patients retired at 23:45 hours and rose at 9:30 hours, for a total nighttime in bed of 585 min while control subjects retired at 23:04 hours (P < 0.01) and rose at 7:42 hours (P < 0.001), for a total nighttime in bed of 518 min (P < 0.001). DM1 patients with and without EDS did not differ relative to their habitual …Cited by: 109
http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2869.2004.00385.x/full
Summary. The aim of this study was to document the clinical picture of excessive daytime sleepiness (EDS) and of other sleep disturbances, and to study the relationship of daytime sleepiness to anthropometric data, muscular impairment, and CTG trinucleotide repeat expansion in myotonic dystrophy type 1 (DM1).
https://www.frontiersin.org/articles/10.3389/fneur.2020.00012/full
Sleep disturbances such as excessive daytime sleepiness, central and obstructive sleep apneas, restless legs syndrome, and rapid eye movement sleep dysregulation are prominent in patients with myotonic dystrophy type 1 (DM1). Mild intellectual deficits presented in many patients with DM1.
https://www.researchgate.net/publication/6931352_Sleep_complaints_in_patients_with_myotonic_dystrophy
Sleep disturbances are seen in about 30-40 percent patients with myotonic dystrophy. Excessive daytime sleepiness (EDS) was the most commonly observed …
https://www.deepdyve.com/lp/wiley/sleep-complaints-in-patients-with-myotonic-dystrophy-FPbY9hwi6W
Mar 01, 2004 · Sleep complaints in patients with myotonic dystrophy Sleep complaints in patients with myotonic dystrophy Laberge, Luc; Bégin, Paul; Montplaisir, Jacques; Mathieu, Jean 2004-03-01 00:00:00 Summary The aim of this study was to document the clinical picture of excessive daytime sleepiness (EDS) and of other sleep disturbances, and to study the relationship of daytime …
https://www.myotonic.org/sleep-and-disordered-breathing-dm2
Finally, the potential correlation of pain, that is so characteristic of DM2, and sleep disruption has not been fully studied and should be an important component of future natural history studies of patients with DM2. Reference: Sleep Complaints, Sleep and Breathing Disorders in Myotonic Dystrophy Type 2.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259012/
Sleep disorders in myotonic dystrophy type 1 (DM1) are common and include sleep disordered breathing (SDB), hypersomnia, and fatigue. Little is known regarding the occurrence of sleep disturbance in myotonic dystrophy type 2 (DM2). We hypothesized that DM2 patients may frequently harbor sleep disorders.Cited by: 19
https://www.sciencedirect.com/science/article/pii/S0960896609000832
We assessed the relationship and clinical correlates of fatigue and Excessive Daytime Sleepiness (EDS) in 200 myotonic dystrophy type 1 (DM1) patients by means of questionnaire and neuropsychological evaluation. Fatigue levels were higher in patients with EDS and daytime sleepiness levels higher in patients with excessive fatigue.Cited by: 53
https://www.myotonic.org/treating-sleep-disorders-dm1
Patient-reported data from MDF’s Myotonic Dystrophy Family Registry (MDFR) indicate that impaired sleep or daytime sleepiness are among the most prevalent symptoms of DM1, experienced by over 76% of patients. Despite the prevalence and substantial burden imposed by sleep disorders, studies report that many patients do not receive treatment.
https://www.sleepassociation.org/sleep-news/patients-muscular-dystrophy-benefit-sleep-disorder-therapy/
Jan 17, 2017 · Most patients with myotonic dystrophy type 1 (DM1) also suffer from respiratory and sleep disorders. DM1 is the most common form of muscular dystrophy found in adults. Recent research published in the Journal of Neuromuscular Diseases notes that due to the variety of sleep difficulties in DM1 patients, the treatments often do not work on a one-size-fits-all model.
https://www.alpfmedical.info/obstructive-sleep/myotonic-dystrophy.html
Jan 21, 2020 · In these patients, nocturnal hypoxemia and hypercapnea are often seen and may be more severe during REM sleep (85) (Fig. 5). Obese MD. FIGURE 4 Myotonic dystrophy and central apnea. Polysomnography epoch of a patient with myotonic dystrophy demonstrating central sleep apnea.
https://www.pharmacytimes.com/news/treating-sleeprelated-symptoms-in-muscular-dystrophy-proves-difficult
“Excessive daytime sleepiness is a common problem for people with myotonic dystrophy, affecting between 33% and 80% of patients,” said lead investigator Sophie D. West, MD. “Other contributing causes can be attributed to poor sleep patterns, obstructive sleep apnea (OSA), respiratory failure, periodic limb movements during sleep, or narcolepsy features."
https://link.springer.com/article/10.1007/s11910-019-0924-0
Feb 09, 2019 · Purpose of Review. To update the current knowledge concerning sleep complaints and breathing disorders in myotonic dystrophy type 2 (DM2) and to better understand if sleep and breathing symptoms may add a further clinical definition of DM2.Cited by: 2
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5397409/
Apr 20, 2017 · Sleep complaints in patients with myotonic dystrophy. J. ... Loss of serotonin-containing neurons in the raphe of patients with myotonic dystrophy: a quantitative immunohistochemical study and relation to hypersomnia. Neurology 50, 535–538. 10.1212/WNL.50.2.535 ...Cited by: 28
https://www.sciencedaily.com/releases/2017/01/170113132926.htm
Jan 13, 2017 · Myotonic dystrophy type 1 (DM1) is the most common adult muscular dystrophy, and many patients with DM1 suffer from various sleep and respiratory disorders. In …
http://sciencesleep.org/ziliao/Sleep%20complaints%20in%20patients%20with%20myotonic%20dystrophy.pdf
sleepiness (EDS) and of other sleep disturbances, and to study the relationship of daytime sleepiness to anthropometric data, muscular impairment, and CTG trinucle-otide repeat expansion in myotonic dystrophy type 1 (DM1). A total of 157 DM1 patients were surveyed using a modified version of the Sleep Questionnaire and
https://musculardystrophynews.com/2017/01/16/md-patients-may-benefit-targeted-therapy-for-sleep-disorders/
Jan 16, 2017 · In myotonic dystrophy type 1 (DM1), sleep disorders are common, with excessive daytime sleepiness (EDS) as a predominant feature. “Excessive daytime sleepiness is a common problem for people with myotonic dystrophy, affecting between 33% and 80% of patients.
https://www.symptoma.com/en/info/myotonic-dystrophy
Myotonic dystrophy is a kind of multisystem disease, which is inherited in nature. It is a chronic disease condition that gradually progresses, causing muscle wasting, myotonia, heart defects and development of cataracts.…Myotonic Dystrophy (MD): Read more about Symptoms, Diagnosis, Treatment, Complications, Causes and Prognosis.
https://www.sciencedirect.com/science/article/pii/S1087079208000099
Coexisting OSA is particularly likely in obese patients, and in patients with associated macroglossia, which is seen in DMD 1 or in patients with craniofacial abnormalities such as in myotonic dystrophy (Steinert's disease). Diagnostic sleep studies may be necessary to characterize the etiology of sleep related hypoxemia, depending on the clinical features.Cited by: 32
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